Overview


1. Due to the lack of a standardized system for evaluating the immunodeficiency, an objective choice of the appropriate immunodeficient mouse strains to be used for tumor engrafting experiments is difficult.

2. We developed a tumor engraftment index (TEI) to quantify the immunodeficiency.

3. 1) TEI helps researcher choose an appropriate immunodeficient mouse strain for tumor engrafting experiments.
    2) TEI provides a platform to compare the immunodeficiency of a new mouse strain with the well-established immunodeifient mouse strains.

RMA-GFP or B16F10 cells


High:1x106,Medium:1x105,Low:1x104

K562 or A549 cells


High:1x106,Medium:1x105,Low:1x104